Adamo P, Ladomery MR. The function of TFF3 in prostate cancer has not been well studied. However, we also determined that promoter DNA methylation of the ERG gene, which had not been previously described, is a common event in human prostate cancer. Previous studies have described PTEN loss as a subclonal event after ERG gene fusion within a given established prostatic carcinoma clone [ 29 ]. Flow diagram for selection of informative and cancer-specific probes. On the other hand, it has been reported that both ERG rearrangements and loss of PTEN are frequent and concomitant events that can cooperate in PrCa progression [ 14 , 20 , 26 — 28 ]. Single and combined alterations according to the different GS categories.

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AmazonGlobal Ship Orders Internationally. Get fast, free shipping with Amazon Prime. Single and combined alterations according to the different GG categories.

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Moreover, Leinonen et a. In summary, DNA methylation bead arrays are an effective method to determine the DNA methylation status of many genes simultaneously in cancer. Trefoil factor 3 overexpression in prostatic carcinoma: Representative gels are shown.

Trefoil factor 3 is overexpressed in human prostate cancer. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.


To account for deviation from normality of the combined data, we performed permutation tests to assess the significance of the variance components. Methods Patient samples and controls for the microarray.

J Roy Statist Soc B. On the other hand, the percentage of cases with one alteration was similar across the different GS or GG subgroups. Adjacent normal tissue was used as an internal reference point for intensity scoring. Am J Surg Pathol. In Gleason score GS 6 biopsies, PTEN loss has been proposed as a potential predictor of upgrading at radical prostatectomy [ 3132 ].

ChIP experiments were performed as described with modifications. Functional studies demonstrated that ERG has an inhibitory effect on TFF3 expression in hormone-naive cancer but not in the castration-resistant state.

For a given experiment, each assay was performed in triplicate.

Understanding how ERG directly regulates downstream targets is an important step in developing targets to key signaling pathways. Journal List Neoplasia v.

National Center for Biotechnology InformationU. ETS gene fusions in errg cancer: ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer.

At the completion of the morphologic evaluation and of the gene expression profiling data quality assessment, interpatient and intrapatient sample correlations were assessed. The lines indicate the relative number of significant reads that mapped to erv indicated region. The function of TFF3 in prostate cancer has not been well studied.


All of them were FFPE. While genetic events such as mutations commonly found in other epithelial malignancies are rare in prostate cancer, there is a wealth of information about the importance of epigenetic changes in this disease. The CRPC and control samples expression data were q-splined together with the median array as the target. This relationship was not observed in HNPC data not shown.

After centrifugation, the cells were washed with serum-free medium and centrifuged. In er with the results of Perner et al. Some authors have not found any association between this rearrangement and the clinical-pathological sl-003 of the tumors or their prognosis [ 910 ].

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Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Author information Article notes Copyright and License information Disclaimer. Wl-0033 gene fusions in prostate cancer.